Adolescent on Dialysis
Adolescent on Dialysis

WHAT MORE MAY BE

BEHIND THE STONE?

Recurrent and/or unusual* kidney stones in an adult or any kidney stone in a child may be early signs of a metabolic stone disease with potentially devastating consequences, such as primary hyperoxaluria type 1 (PH1).1-4

More About PH1

Calcium Oxalate Stone - Kidney Stone

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LEAVE NO KIDNEY STONE UNTURNED

Any unusual stone may be a sign of a metabolic stone disease, such as primary hyperoxaluria type 1, and merits further investigation1,2

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Children or Adolescents

Any stone or a family history of stones may be red flags.1,3-5

Adults

Recurrent and/or unusual stones* may be red flags.

*Including multiple, bilateral, and/or large stones.1,6-9

Testing

A 24-hour urine test can be used to help detect metabolic stone disease.10-12

Go to PH1 Testing

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PH1 IS A RARE, PROGRESSIVE, POTENTIALLY LIFE-THREATENING INHERITED DISEASE.3,4

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PH1 IS A RARE, PROGRESSIVE, POTENTIALLY LIFE-THREATENING INHERITED DISEASE.3,4

Primary Hyperoxaluria Type 1 (PH1) Mechanism of Disease - Liver-Kidney Interaction

PH1 is caused by autosomal recessive mutations in the AGXT gene, leading to overproduction of oxalate in the liver.3,4 Over time, oxalate overproduction can lead to progressive kidney function decline.2,4 

Explore PH1

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PH1: UNDERDIAGNOSED AND DELAYED DIAGNOSIS8,13‑16

Diagnosis is often delayed when PH1 is overlooked

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of PH1 patients may be undiagnosed, although data on prevalence are limited.16

5.5YEARS

is the median delay in adults between onset of clinical manifestations and diagnosis.14

of diagnoses in adults occur after progression to end-stage kidney disease (ESKD).13,17-20

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Recognize the Signs

Download the PH1 Diagnosis Overview

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PH1 MANAGEMENT APPROACHES

Current management approaches to PH1 aim at enhancing clearance of oxalate, inhibiting oxalate crystallization, or lowering oxalate production by the liver.3,4,11

Management

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